Design, implement, and run automated benchmarking and validation pipelines for AI-driven genomic interpretation. Expand regression datasets, execute large-scale validation across curated VCFs, surface accuracy regressions, build automated QA for AI releases, and integrate validation into CI/CD with dashboards and documented failure modes.
Sequencing is building the interface between humanity and its DNA.
Using clinical-grade whole genome sequencing, AI, and a rapidly expanding ecosystem of genomic applications, we help people better understand themselves, their health, and their future through their DNA.
The human genome is one of the most valuable and underutilized resources in the world. Our mission is to transform the human genome into a lifelong source of personalized guidance and build the trusted home for every genome on Earth.
As the world’s largest direct-to-consumer whole genome sequencing platform, Sequencing is helping define the future of AI-powered personalized health.
We’re a profitable, venture-backed, fully remote company building category-defining products that help people better understand themselves through their DNA.
At Sequencing, you'll build and operate the evaluation and validation infrastructure that keeps our AI systems correct, reliable, and regression-protected. This is an execution-focused role: you'll design, implement, and maintain the benchmarking systems that continuously test AI outputs against curated genomic datasets, partnering closely with the AI Bioinformatics Engineering Lead to turn interpretation standards into measurable, operational systems. You are detail-oriented, have a systems-thinking mindset and you notice the one VCF out of ten thousand that doesn't look right
The Opportunity
- Build and run automated evaluation pipelines for AI outputs end-to-end.
- Expand regression datasets that cover variant normalization, transcript ambiguity, and disease-level mapping.
- Execute large-scale validation runs across curated VCF datasets, track performance over time, and surface accuracy regressions the moment they appear.
- Grow a structured question bank using and related datasets, encoding the edge cases that matter most.
- Ship automated regression tests for every AI release and build dashboards that make variant-level and case-level accuracy visible to the whole team.
- Partner with engineering to wire validation directly into CI/CD, and diagnose and document failure modes as they emerge.
Who you are
- Degree in Bioinformatics, Computational Biology, Genetics, or a related field.
- Deep, hands-on experience with VCFs and real-world genomic datasets.
- Fluency with ClinVar, dbSNP, HGVS standards, and transcript mapping.
- A track record building evaluation frameworks or testing pipelines, Langfuse or similar.
- Experience evaluating LLM-based systems and standing up automated QA at scale.
.
- Comprehensive medical, dental, and vision insurance coverage
- 401(k) with company matching
- Paid time off (PTO)
- Paid volunteer time off
- Fully remote work with home office stipend
- Parental bonding leave
- Clinical-grade whole genome sequencing for you and your family (private and confidential)
- Redefine how people understand themselves through their DNA
- Build category-defining products alongside scientists, engineers, and innovators
- Contribute to technology that will improve and extend millions of lives
- Shape one of the most important emerging categories in AI and healthcare
Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.
Sequencing Inc. may use artificial intelligence (AI) or automated tools as part of the recruiting and hiring process, including for application screening and candidate evaluation. These tools may analyze information provided in your application materials or during the hiring process. Where required by applicable law, candidates may request a reasonable accommodation or an alternative selection process by contacting [email protected].
Similar Jobs
Big Data • Food • Hardware • Machine Learning • Retail • Automation • Manufacturing
Lead program-level change strategy, readiness framework, and QA for change deliverables. Standardize key user learning journeys, manage the integrated change plan, oversee risks and issues, direct Functional Change Leads, represent change at leadership forums, and build lasting organizational change capability.
Top Skills:
ConfluenceJIRAMicrosoft TeamsMs ProjectO9OracleSalesforceSAPSharepointSmartsheet
Artificial Intelligence • Productivity • Software • Automation
The Manager, Sales Assist will lead a team to drive sales and customer growth, coach representatives, and engage with clients using data-driven strategies.
Top Skills:
GongHubspot
Information Technology
As a Senior Backend Engineer at DuckDuckGo, you'll lead backend projects, mentor engineers, and develop AI-enhanced features for the company's privacy-centric product line.
Top Skills:
Ai ToolingGoNode.jsPerlRag Pipelines
What you need to know about the Manchester Tech Scene
Home to a £5 billion digital ecosystem, including MediaCity, which consists of major players like the BBC, ITV and Ericsson, Manchester is one of the U.K.'s top digital tech hubs, at the forefront of advancements in film, television and emerging sectors like as e-sports, while also fostering a community of professionals dedicated to pushing creative and technological boundaries.
